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What is Beta Glucan
Your immune system is built to learn.
Immune intelligence starts at the cellular level, where BWH-85® Beta Glucan works with the innate immune system to build greater adaptability and readiness over time.
Why immune intelligence matters.
Age with resilience
Support immune function and physiological stability as the body changes over time.
Maintain balance
Help maintain healthy, appropriately regulated inflammatory activity.
Respond with resilience
Stay better equipped during periods of physical and physiological stress.
Recover and restore
Support the processes involved in recovery and tissue repair.
Stay adaptable
Support an immune system capable of adjusting to the challenges it encounters.
Your immune system helps you respond to challenges, recover from stress, maintain balance, and stay resilient over time, making immune intelligence essential to both everyday health and healthy aging.
Your immune system is built to recognize, learn, and adapt.
Your innate immune system is constantly scanning for what matters. When it recognizes certain biological patterns, it can adapt in ways that leave immune cells better prepared for future challenges.
That process is known as trained immunity.
BWH-85® Beta Glucan works with this biology at the cellular level, helping the innate immune system become more responsive, coordinated, and prepared over time.
That is immune intelligence.
ThreatImmune Cell
What is beta glucan?
Beta Glucan is the most studied, natural immune system supplement in the world! It is a naturally occurring polysaccharide found in sources including yeast, fungi, and grains. But not all beta glucans are the same. The source, structure, and purity can differ significantly, which influences how they interact with the immune system.
BWH-85® is an insoluble beta-1,3/1,6-glucan derived from baker’s yeast (Saccharomyces cerevisiae) and standardized to greater than 85% beta glucan.
The beta-1,3/1,6 structure and ≥85% purity of BWH-85® is recognized by key receptors on innate immune cells, supporting reliable recognition and a more consistent biological response.
How BWH-85® works in the body
BWH-85® Beta Glucan is recognized by pattern-recognition receptors on innate immune cells, including Dectin-1 and Complement Receptor 3 (CR3).
From there, a series of coordinated changes takes place that helps explain the biology behind trained immunity.
The immune system recognizes something meaningful.
BWH-85® is identified by receptors on innate immune cells including neutrophils, monocytes, macrophages, and dendritic cells. That recognition begins a cascade of cellular events associated with trained immunity.
Immune cells become more capable of working together.
Receptor engagement influences immune-cell activity and communication, including coordination between innate and adaptive immunity, downstream activity involving natural killer cells, and movement of immune cells to where they are needed.
Cells change how they function.
Research shows that beta-glucan recognition can influence cellular metabolism and intracellular pathways involved in immune coordination and balanced inflammatory activity. These changes help immune cells adapt how they generate energy and respond to future challenges.
The immune system carries the lesson forward.
Repeated exposure to recognizable beta glucan can support functional training of innate immune cells. This is trained immunity—changes in cellular function and gene expression that can leave the immune system better prepared for future challenges, including ones it has not encountered before.
Healthy aging starts with immune intelligence.
Healthy aging depends on how well the body can adapt, recover, regulate inflammation, repair, and maintain balance over time.
In a 12-week TruDiagnostic study, BWH-85® was associated with measurable changes in biological age across seven systems.
What sets BWH-85® apart
Not every beta glucan has the same source, structure, purity, or consistency. BWH-85® is produced around the specific characteristics that matter for reliable recognition by the innate immune system.
Compare BWH-85® to other
Feature
Vitamin C
Elderberry
Fatty Acid
Collagen
Primary role
Trained immunity &
immune intelligence
immune intelligence
Essential nutrient
& antioxidant
& antioxidant
Traditional generic
immune support
immune support
Support cellular
health
health
Support connective
tissues
tissues
Acts directly on innate immune training
Not established
Not established
Supports pattern-recognition pathways
Not established
Not established
Designed for ongoing immune adaptation
Not established
Not established
Standardized for immune activity
Varies
Varies
Evidence specific to trained immunity
Limited/indirect
Limited
Not established
Feature
Typical Beta Glucan
Beta-1,3/1,6 structure
Varies
Standardized purity
≥85%
Baker's yeast derived
Varies
Structurally intact
Third-party lot tested
Limited
Consistent specifications
Purity matters
Purity directly affects how well beta glucan works. Even a small reduction in purity can cause a much larger drop in biological activity, which is why BWH-85® is standardized to a minimum 85% purity for consistent, reliable results.
Only the top 10% of beta glucan produced meets our stringent purification standards.
A purity protected by Over 200 patents
Here are just a sample of the hundreds of patents protecting our production process and clinical glucan applications:
- USPTO.gov Patent Number: 6,242,594 | linkTitle: Process for glucan preparation and therapeutic uses of glucan
- USPTO.gov Patent Number: 7,550,584 | linkTitle: Methods of purifying beta glucans
- USPTO.gov Patent Number: 8,859,759 | linkTitle: Particulate-soluble glucan preparation
- USPTO.gov Patent Number: 8,946,193 | linkTitle: Medical uses of glucans
- USPTO.gov Patent Number: 7,622,575 | linkTitle: Therapeutic uses of glucan
- USPTO.gov Patent Number: 8,865,679 | linkTitle: Use of beta-glucans against biological warfare weapons and pathogens including anthrax
- USPTO.gov Patent Number: 8,563,531 | linkTitle: Methods of using beta glucan as a radioprotective agent
Safety
Baker's yeast (Saccharomyces cerevisiae) has been given the FDA's GRAS (Generally Recognized as Safe) rating, one of the highest safety ratings a substance can achieve. This highly coveted accolade ensures there are no known side effects or adverse reactions associated with taking this product.
BWH-85® Beta Glucan products are manufactured in ISO 9000 facilities and they strictly adhere to ISPE's Good Manufacturing Practices (GMP). The final product is evaluated by independent third-party agencies, with each lot receiving a Certificate of Analysis.
50+ years of beta glucan research
Over 50 years of research have been performed on beta glucan. During that time, thousands of studies have been published on PubMed.gov, and hundreds of studies on Glucan are currently being conducted on ClinicalTrials.gov
Beta glucan has been studied at numerous universities and teaching hospitals
Our beta glucan has been published in these fine medical journals
- Journal of Nutritional Science
- American Journal of Immunology
- Oriental Pharmacy and Experimental Medicine
- The Journal of the American Nutraceutical Association (JANA)
- Journal of Medicinal Food
- Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
- Toxins — Open Access Toxinology Journal
- Annals of Translational Medicine
- Journal of Nutrition and Health Sciences
- International Journal of Clinical and Experimental Medical Sciences
- Open Glycoscience
- Pathology Discovery (Herbert Open Access Journals)
- Anticancer Research (International Journal of Cancer Research and Treatment)
- Journal of Tumor
- Food Hydrocolloids
- Proceedings of the National Academy of Sciences of the United States of America (PNAS)
- North American Journal of Medical Sciences (NAJMS)
- International Clinical Pathology Journal
- Molecules — Open Access Organic Chemistry Journal
- Journal of Nature and Science